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CAS 274-00-0 Thiazolo[4,5-b]pyrazine molecular structure lightbox
CAS RN: 274-00-0

Thiazolo[4,5-b]pyrazine

Product Availability

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1 package records1 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250430 100mg / 250mg / 1g Confirm by inquiry Shanghai Inquiry
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274-00-0 / [1,3]thiazolo[4,5-b]pyrazine

Thiazolo[4,5-b]pyrazine | [1,3]thiazolo[4,5-b]pyrazine | SCHEMBL219610

Standard CAS: 274-00-0 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
274-00-0
Multi CAS
No
Molecular Formula
C5H3N3S
Molecular Weight
137.160000
Exact Mass
137.004768
SMILES
C1=CN=C2C(=N1)N=CS2
InChI
InChI=1S/C5H3N3S/c1-2-7-5-4(6-1)8-3-9-5/h1-3H
InChIKey
HEIZPACCIHXHKV-UHFFFAOYSA-N
Synonyms
Thiazolo[4,5-b]pyrazine [1,3]thiazolo[4,5-b]pyrazine SCHEMBL219610 SCHEMBL971983 SCHEMBL1328659

Computed Properties

Structural Parameters

Heavy atom count
9
Aromatic heavy atom count
9
H-bond acceptors
4
Molar refractivity
35.21
TPSA
38.67

LogP / Solubility

WLOGP
1.09
MLOGP
0.95
XLogP3
0.9
Consensus LogP
0.98
Log S (ESOL)
-2.11
Class (ESOL)
Moderately soluble
Log S (Ali)
-1.47
Class (Ali)
Soluble
Log S (SILICOS-IT)
-1.45
Class (SILICOS-IT)
Soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.79

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
1.5

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