[email protected]
CAS 267243-68-5 N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine molecular structure lightbox
CAS RN: 267243-68-5

N4-(3-chloro-4-fluorophenyl)-7-(3-Morpholinopropoxy)quinazoline-4,6-diaMine

Product Availability

Choose a grade to view its available package options.

1 package records0 with current stock1 grade group
Batch No.PackageAvailabilityLead TimeInquiry
Batchno.20250818 25mg / 100mg Out of stock 8-10 business days Inquiry
  • Product code: starshine_CAS267243-68-5
  • Purity/Analytical Methods: >99.0%
GET A QUOTE

267243-68-5 / 4-N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)quinazoline-4,6-diamine

Standard CAS: 267243-68-5 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
267243-68-5
Multi CAS
No
Molecular Formula
C21H23ClFN5O2
Molecular Weight
431.900000
Exact Mass
431.152431
SMILES
C1COCCN1CCCOC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)N
InChI
InChI=1S/C21H23ClFN5O2/c22-16-10-14(2-3-17(16)23)27-21-15-11-18(24)20(12-19(15)25-13-26-21)30-7-1-4-28-5-8-29-9-6-28/h2-3,10-13H,1,4-9,24H2,(H,25,26,27)
InChIKey
HBUGOFLVIGUDIA-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
30
Aromatic heavy atom count
16
Fraction Csp3
0.33
Rotatable bonds
7
H-bond acceptors
7
H-bond donors
2
Molar refractivity
116.01
TPSA
85.53

LogP / Solubility

WLOGP
3.85
MLOGP
3.42
XLogP3
3.5
Consensus LogP
3.59
Log S (ESOL)
-4.88
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.88
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-6.5
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.62

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
3

Customers Also Viewed

Get In Touch

Contact Us