CAS RN: 256376-24-6
BAY 41-2272
Product Availability
Choose a grade to view its available package options.
5 package records4 with current stock1 grade group
- Product code: starshine_CAS256376-24-6
- Purity/Analytical Methods: >99.0%
256376-24-6 / 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-4-amine
Basic Information
CAS
256376-24-6
Multi CAS
Yes
Molecular Formula
C20H17FN6
Molecular Weight
360.400000
Exact Mass
360.149873
InChI
InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChIKey
ATOAHNRJAXSBOR-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
27
Aromatic heavy atom count
21
Fraction Csp3
0.2
Rotatable bonds
4
H-bond acceptors
6
H-bond donors
1
Molar refractivity
100.44
TPSA
82.51
LogP / Solubility
WLOGP
3.54
MLOGP
3.13
XLogP3
3.1
Consensus LogP
3.26
Log S (ESOL)
-4.61
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.07
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.42
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.41
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5
Customers Also Viewed
-
![CAS 256376-59-7 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester molecular structure](data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E)
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester
- CAS RN: 256376-59-7
- Product Code: SSC-121790
-
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide
- CAS RN: 256376-62-2
- Product Code: SSC-121791
-
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
- CAS RN: 256376-65-5
- Product Code: SSC-121792
-
2,6-bis[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-Pyridine
- CAS RN: 256377-24-9
- Product Code: starshine_CAS256377-24-9
- Purity/Analytical method: >99.0%
-
-
(R)-(+)-2,2′-Bis[di(3,4,5-trimethoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl,min.97%
- CAS RN: 256390-47-3
- Product Code: SSC-121806
![CAS 256376-59-7 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/256376-59-7.gif)
![CAS 256376-62-2 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/256376-62-2.gif)
![CAS 256376-65-5 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/256376-65-5.gif)
![CAS 256377-24-9 2,6-bis[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-Pyridine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/256377-24-9.gif)
![CAS 256390-47-3 (R)-(+)-2,2′-Bis[di(3,4,5-trimethoxyphenyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl,min.97% molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/256390-47-3.gif)