CAS RN: 192185-71-0
Tipifarnib (S enantioMer)
Product Availability
Choose a grade to view its available package options.
4 package records2 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20260515 | 2mg / 5mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS192185-71-0
- Purity/Analytical Methods: >99.0%
192185-71-0 / 6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
Basic Information
CAS
192185-71-0
Multi CAS
No
Molecular Formula
C27H22Cl2N4O
Molecular Weight
489.400000
Exact Mass
488.117067
SMILES
CN1C=NC=C1[C@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
InChI
InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m0/s1
InChIKey
PLHJCIYEEKOWNM-MHZLTWQESA-N
Computed Properties
Structural Parameters
Heavy atom count
34
Aromatic heavy atom count
27
Fraction Csp3
0.11
Rotatable bonds
4
H-bond acceptors
5
H-bond donors
1
Molar refractivity
138.36
TPSA
65.84
LogP / Solubility
WLOGP
5.5
MLOGP
4.87
XLogP3
4.1
Consensus LogP
4.82
Log S (ESOL)
-6.66
Class (ESOL)
Insoluble
Log S (Ali)
-7.54
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.88
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.8
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4
Customers Also Viewed
-
-
4,4′-(1,4-phenylenebis(ethyne-2,1-diyl))dibenzaldehyde
- CAS RN: 192188-70-8
- Product Code: starshine_CAS192188-70-8
- Purity/Analytical method: >99.0%
-
-
3-IODO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS RN: 192189-10-9
- Product Code: SSC-089944
-
-
![CAS 192189-15-4 1-Boc-3-broMo-1H-pyrrolo[3,2-b]pyridine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/192189-15-4.gif)
