CAS RN: 185039-89-8
PD0166285
Product Availability
Choose a grade to view its available package options.
13 package records10 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20260306 | 100mg | In stock | Shanghai | Inquiry | |
| Batchno.20260203 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20251017 | 1mg | In stock | Shanghai, Tianjin, Wuhan | Inquiry | |
| Batchno.20260326 | 250mg | Out of stock | Inquiry | ||
| Batchno.20250625 | 25mg | In stock | Shanghai | Inquiry | |
| Batchno.20251103 | 50mg | In stock | Shanghai | Inquiry | |
| Batchno.20250225 | 5mg | In stock | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250813 | 5mg / 25mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS185039-89-8
- Purity/Analytical Methods: >99.0%
185039-89-8 / 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one
Basic Information
CAS
185039-89-8
Multi CAS
No
Molecular Formula
C26H27Cl2N5O2
Molecular Weight
512.400000
Exact Mass
511.154181
SMILES
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl
InChI
InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
InChIKey
IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
35
Aromatic heavy atom count
22
Fraction Csp3
0.27
Rotatable bonds
9
H-bond acceptors
7
H-bond donors
1
Molar refractivity
143.24
TPSA
72.28
LogP / Solubility
WLOGP
5.77
MLOGP
5.11
XLogP3
5.6
Consensus LogP
5.49
Log S (ESOL)
-6.52
Class (ESOL)
Insoluble
Log S (Ali)
-7.93
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.86
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.75
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.56
Leadlikeness
No
Synthetic Accessibility
3
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