CAS RN: 1454846-35-5
Lorlatinib (PF-06463922)
Product Availability
Choose a grade to view its available package options.
9 package records9 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250228 | 100mg | In stock | Shanghai, Tianjin | Inquiry |
| Batchno.20260522 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20250509 | 1g | In stock | Shanghai | Inquiry |
| Batchno.20250601 | 1mg | In stock | Shanghai | Inquiry |
| Batchno.20251104 | 250mg | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20250701 | 5g | In stock | Shanghai | Inquiry |
| Batchno.20260605 | 5mg | In stock | Shanghai | Inquiry |
| Batchno.20251016 | 5mg / 25mg / 100mg / 1g | Confirm by inquiry | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250420 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS1454846-35-5
- Purity/Analytical Methods: >99.0%
1454846-35-5 / (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
Basic Information
CAS
1454846-35-5
Multi CAS
No
Molecular Formula
C21H19FN6O2
Molecular Weight
406.400000
Exact Mass
406.155352
SMILES
C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
InChI
InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
InChIKey
IIXWYSCJSQVBQM-LLVKDONJSA-N
Computed Properties
Structural Parameters
Heavy atom count
30
Aromatic heavy atom count
17
Fraction Csp3
0.24
H-bond acceptors
7
H-bond donors
1
Molar refractivity
106.81
TPSA
110.06
LogP / Solubility
WLOGP
2.8
MLOGP
2.49
XLogP3
1.5
Consensus LogP
2.26
Log S (ESOL)
-4.54
Class (ESOL)
Slightly soluble
Log S (Ali)
-4.91
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.63
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.21
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
7
Safety & Transport
Pictogram(s)
Health Hazard
Environmental Hazard
Signal
Warning
GHS Hazard Statements
H341 (75%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H361 (50%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H373 (75%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H400 (25%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (25%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes
P203, P260, P273, P280, P318, P319, P391, P405, and P501
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