[email protected]
CAS 1446113-23-0 Belvarafenib molecular structure lightbox
CAS RN: 1446113-23-0

Belvarafenib

Product Availability

Choose a grade to view its available package options.

4 package records2 with current stock1 grade group
Batch No.PackageAvailabilityInquiry
Batchno.20250128 100mg Out of stock Inquiry
Batchno.20250520 1mg Out of stock Inquiry
Batchno.20260330 25mg In stock Inquiry
Batchno.20251218 5mg In stock Inquiry
  • Product code: SSC-055827
GET A QUOTE
Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
Request Bulk Quote

Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1446113-23-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g ≥95% 0 Out of Stock Beijing Inquiry

1446113-23-0 / 4-amino-N-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide

Standard CAS: 1446113-23-0 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1446113-23-0
Multi CAS
No
Molecular Formula
C23H16ClFN6OS
Molecular Weight
478.900000
Exact Mass
478.077886
SMILES
CC1=C(C2=C(C=C1)C(=NC=C2)NC3=C(C(=CC=C3)Cl)F)NC(=O)C4=CSC5=C4N=CN=C5N
InChI
InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
InChIKey
KVCQTKNUUQOELD-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
33
Aromatic heavy atom count
25
Fraction Csp3
0.04
Rotatable bonds
4
H-bond acceptors
7
H-bond donors
3
Molar refractivity
130.95
TPSA
105.82

LogP / Solubility

WLOGP
5.92
MLOGP
5.24
XLogP3
4.9
Consensus LogP
5.35
Log S (ESOL)
-6.83
Class (ESOL)
Insoluble
Log S (Ali)
-7.76
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.17
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.44

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
No
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5

Customers Also Viewed

Get In Touch

Contact Us