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CAS 1445879-21-9 GSK2837808A molecular structure lightbox
CAS RN: 1445879-21-9

GSK2837808A

Product Availability

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11 package records8 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250523 100mg Out of stock Inquiry
Batchno.20251225 10mg In stock Inquiry
Batchno.20250614 25mg Out of stock Inquiry
Batchno.20250125 50mg In stock Inquiry
Batchno.20250224 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251115 1ml In stock Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260221 100mg In stock Shanghai, Shenzhen Inquiry
Batchno.20250605 10mg In stock Shanghai Inquiry
Batchno.20251224 250mg Out of stock Inquiry
Batchno.20260130 25mg In stock Shanghai Inquiry
Batchno.20260504 50mg In stock Shanghai Inquiry
  • Product code: SSC-055760
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: >98%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1445879-21-9
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g >98% 0 Out of Stock Shanghai Inquiry

1445879-21-9 / 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid

Standard CAS: 1445879-21-9 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1445879-21-9
Multi CAS
No
Molecular Formula
C31H25F2N5O7S
Molecular Weight
649.600000
Exact Mass
649.144276
SMILES
COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC
InChI
InChI=1S/C31H25F2N5O7S/c1-43-29-25(14-35-31(37-29)44-2)16-3-6-24-26(9-16)34-15-27(46(41,42)38-20-4-5-20)28(24)36-21-7-17(30(39)40)8-22(13-21)45-23-11-18(32)10-19(33)12-23/h3,6-15,20,38H,4-5H2,1-2H3,(H,34,36)(H,39,40)
InChIKey
RZBCPMYJIARMGV-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
46
Aromatic heavy atom count
28
Fraction Csp3
0.16
Rotatable bonds
11
H-bond acceptors
10
H-bond donors
3
Molar refractivity
162.33
TPSA
161.86

LogP / Solubility

WLOGP
5.66
MLOGP
5.04
XLogP3
5.6
Consensus LogP
5.43
Log S (ESOL)
-7.16
Class (ESOL)
Insoluble
Log S (Ali)
-8.97
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-9.9
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.66

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Leadlikeness
No
Synthetic Accessibility
5.5

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