CAS RN: 1365267-27-1
X-376
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9 package records8 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20260123 | 100mg / 250mg | Out of stock | 5-7 business days | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20260314 | 100mg | In stock | Shanghai | Inquiry | |
| Batchno.20250223 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20251115 | 1g | In stock | Shanghai | Inquiry | |
| Batchno.20260514 | 1mg | In stock | Shanghai | Inquiry | |
| Batchno.20250108 | 250mg | In stock | Shanghai | Inquiry | |
| Batchno.20260402 | 2mg | In stock | Shanghai | Inquiry | |
| Batchno.20250707 | 50mg | In stock | Shanghai | Inquiry | |
| Batchno.20260104 | 5mg | In stock | Shanghai | Inquiry |
- Product code: starshine_CAS1365267-27-1
- Purity/Analytical Methods: >99.0%
1365267-27-1 / 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
Basic Information
CAS
1365267-27-1
Multi CAS
No
Molecular Formula
C25H25Cl2FN6O3
Molecular Weight
547.400000
Exact Mass
546.134922
SMILES
C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
InChI
InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1
InChIKey
ONPGOSVDVDPBCY-CQSZACIVSA-N
Computed Properties
Structural Parameters
Heavy atom count
37
Aromatic heavy atom count
18
Fraction Csp3
0.28
Rotatable bonds
6
H-bond acceptors
7
H-bond donors
2
Molar refractivity
139.7
TPSA
113.68
LogP / Solubility
WLOGP
4.28
MLOGP
3.81
XLogP3
3.2
Consensus LogP
3.76
Log S (ESOL)
-5.9
Class (ESOL)
Slightly soluble
Log S (Ali)
-7.14
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.49
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.02
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
5
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