![CAS 1286739-19-2 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1286739-19-2.gif)
CAS RN: 1286739-19-2
6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
Product Availability
Choose a grade to view its available package options.
15 package records12 with current stock4 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250805 | 100mg | Out of stock | Inquiry | ||
| Batchno.20250312 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20251118 | 1mg | In stock | Shanghai | Inquiry | |
| Batchno.20250528 | 250mg | Out of stock | Inquiry | ||
| Batchno.20251103 | 25mg | In stock | Shanghai | Inquiry | |
| Batchno.20250119 | 2mg | In stock | Shanghai | Inquiry | |
| Batchno.20260209 | 50mg | In stock | Tianjin | Inquiry | |
| Batchno.20250908 | 5mg | In stock | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20251012 | 5mg / 25mg / 100mg | Out of stock | 5-7 business days | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20251215 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS1286739-19-2
- Purity/Analytical Methods: >99.0%
1286739-19-2 / 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one
Basic Information
CAS
1286739-19-2
Multi CAS
No
Molecular Formula
C29H28ClN7OS
Molecular Weight
558.100000
Exact Mass
557.176457
SMILES
CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C
InChI
InChI=1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34)
InChIKey
DHUJCQOUWQMVCG-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
39
Aromatic heavy atom count
27
Fraction Csp3
0.24
Rotatable bonds
6
H-bond acceptors
9
H-bond donors
1
Molar refractivity
160.46
TPSA
79.18
LogP / Solubility
WLOGP
5.75
MLOGP
5.1
XLogP3
5.3
Consensus LogP
5.38
Log S (ESOL)
-7.04
Class (ESOL)
Insoluble
Log S (Ali)
-8.29
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.78
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.04
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.56
PAINS alerts
1
Leadlikeness
No
Synthetic Accessibility
5.5
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