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CAS 1274933-78-6 4-(2,4-difluorophenyl)piperidin-4-ol molecular structure lightbox
CAS RN: 1274933-78-6

4-(2,4-difluorophenyl)piperidin-4-ol

Product Availability

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4 package records2 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250814 100mg In stock Tianjin Inquiry
Batchno.20250614 100mg / 250mg / 1g Out of stock 8-10 business days Inquiry
Batchno.20260327 1g Out of stock Inquiry
Batchno.20250827 250mg In stock Shanghai, Tianjin Inquiry
  • Product code: starshine_CAS1274933-78-6
  • Purity/Analytical Methods: >99.0%
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1274933-78-6 / 4-(2,4-difluorophenyl)piperidin-4-ol

Standard CAS: 1274933-78-6 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1274933-78-6
Multi CAS
No
Molecular Formula
C11H13F2NO
Molecular Weight
213.220000
Exact Mass
213.096520
SMILES
C1CNCCC1(C2=C(C=C(C=C2)F)F)O
InChI
InChI=1S/C11H13F2NO/c12-8-1-2-9(10(13)7-8)11(15)3-5-14-6-4-11/h1-2,7,14-15H,3-6H2
InChIKey
PUQNYGNTNKBICA-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
15
Aromatic heavy atom count
6
Fraction Csp3
0.45
Rotatable bonds
1
H-bond acceptors
2
H-bond donors
2
Molar refractivity
52.36
TPSA
32.26

LogP / Solubility

WLOGP
1.54
MLOGP
1.35
XLogP3
1.2
Consensus LogP
1.36
Log S (ESOL)
-2.36
Class (ESOL)
Moderately soluble
Log S (Ali)
-2.42
Class (Ali)
Moderately soluble
Log S (SILICOS-IT)
-2.44
Class (SILICOS-IT)
Moderately soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.93

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
1.5

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