CAS RN: 127-07-1
Hydroxyurea
Product Availability
Choose a grade to view its available package options.
4 package records2 with current stock1 grade group
- Product code: SSC-034370
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 500g
- Available purity: ≥97%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 500g | ≥97% | 0 Out of Stock | Shanghai | Inquiry |
127-07-1 / hydroxyurea
Basic Information
CAS
127-07-1
Multi CAS
No
Molecular Formula
CH4N2O2
Molecular Weight
76.055000
Exact Mass
76.027277
SMILES
C(=O)(N)NO
InChI
InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChIKey
VSNHCAURESNICA-UHFFFAOYSA-N
Physical Properties
Melting Point
291 to 295 °F (decomposes) (NTP, 1992)
133-136
141 °C
MP: 133-136 °C. Somewhat hygroscopic
142 - 146 °C
Boiling Point
Decomposes (NTP, 1992)
Decomposes
Physical Description
Hydroxyurea appears as odorless or almost odorless white to off-white crystalline solid. Tasteless. (NTP, 1992)
Solid
Appearance
Needles from alcohol
White, crystalline powder
Needles from ethanol, crystals in 2 forms
State
Solid
Storage Conditions
STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Moisture sensitive. Keep in a dry place.
Store at 20 deg to 25 °C (68 deg to 77 °F)
Computed Properties
Structural Parameters
Heavy atom count
5
H-bond acceptors
2
H-bond donors
3
Molar refractivity
14.51
TPSA
75.35
LogP / Solubility
WLOGP
-0.96
MLOGP
-0.86
XLogP3
-1.8
Consensus LogP
-1.21
Log S (ESOL)
0.29
Class (ESOL)
Highly soluble
Log S (Ali)
0.51
Class (Ali)
Highly soluble
Log S (SILICOS-IT)
0.64
Class (SILICOS-IT)
Highly soluble
ADME
GI absorption
Low
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.86
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
1
Safety & Transport
Pictogram(s)
Health Hazard
Signal
Danger
GHS Hazard Statements
H340 (86.2%): May cause genetic defects [Danger Germ cell mutagenicity]
H360 (13.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H361 (82.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H340: May cause genetic defects [Danger Germ cell mutagenicity]
H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
Precautionary Statement Codes
P203, P280, P318, P405, and P501
