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CAS 1243244-14-5 LGK-974 molecular structure lightbox
CAS RN: 1243244-14-5

LGK-974

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11 package records11 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250603 100mg In stock Shanghai, Shandong Inquiry
Batchno.20250223 25mg In stock Shanghai Inquiry
Batchno.20250522 5mg In stock Shanghai, Guangdong Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260331 100mg In stock Shanghai Inquiry
Batchno.20260108 10mg In stock Shanghai Inquiry
Batchno.20250920 1mg In stock Shanghai Inquiry
Batchno.20251218 250mg In stock Shanghai Inquiry
Batchno.20250426 25mg In stock Shanghai Inquiry
Batchno.20250401 2mg In stock Shanghai Inquiry
Batchno.20260216 50mg In stock Shanghai Inquiry
Batchno.20250919 5mg In stock Shanghai Inquiry
  • Product code: starshine_CAS1243244-14-5
  • Purity/Analytical Methods: >99.0%
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1243244-14-5 / 2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide

Standard CAS: 1243244-14-5 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1243244-14-5
Multi CAS
No
Molecular Formula
C23H20N6O
Molecular Weight
396.400000
Exact Mass
396.169859
SMILES
CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4
InChI
InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChIKey
XXYGTCZJJLTAGH-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
30
Aromatic heavy atom count
24
Fraction Csp3
0.13
Rotatable bonds
5
H-bond acceptors
6
H-bond donors
1
Molar refractivity
114.54
TPSA
93.55

LogP / Solubility

WLOGP
3.79
MLOGP
3.36
XLogP3
1.8
Consensus LogP
2.98
Log S (ESOL)
-4.95
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.55
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.99
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.44

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

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