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CAS 1223-16-1 BIS(P-AMINOPHENOXY)DIMETHYLSILANE molecular structure lightbox
CAS RN: 1223-16-1

BIS(P-AMINOPHENOXY)DIMETHYLSILANE

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3 package records3 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260214 1g In stock Shanghai Inquiry
Batchno.20250530 25g In stock Shanghai, Shandong Inquiry
Batchno.20260417 5g In stock Shanghai, Hebei Inquiry
  • Product code: starshine_CAS1223-16-1
  • Purity/Analytical Methods: >99.0%
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1223-16-1 / 4-[(4-aminophenoxy)-dimethylsilyl]oxyaniline

Standard CAS: 1223-16-1 Multi CAS: No
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1223-16-1
Multi CAS
No
Molecular Formula
C14H18N2O2Si
Molecular Weight
274.390000
Exact Mass
274.113754
SMILES
C[Si](C)(OC1=CC=C(C=C1)N)OC2=CC=C(C=C2)N
InChI
InChI=1S/C14H18N2O2Si/c1-19(2,17-13-7-3-11(15)4-8-13)18-14-9-5-12(16)6-10-14/h3-10H,15-16H2,1-2H3
InChIKey
IYTXQZMZTQHONB-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
19
Aromatic heavy atom count
12
Fraction Csp3
0.14
Rotatable bonds
4
H-bond acceptors
4
H-bond donors
2
Molar refractivity
80.45
TPSA
70.5

LogP / Solubility

WLOGP
3.01
MLOGP
2.66
XLogP3
3.01
Consensus LogP
2.89
Log S (ESOL)
-3.64
Class (ESOL)
Poorly soluble
Log S (Ali)
-3.98
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-4.42
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.26

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
PAINS alerts
1
Brenk alerts
1
Leadlikeness
Yes
Synthetic Accessibility
1.5

Safety & Transport

Pictogram(s)
Irritant
Signal
Warning
GHS Hazard Statements
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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