CAS RN: 119413-54-6
Topotecan Hydrocholoride
Product Availability
Choose a grade to view its available package options.
11 package records10 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250704 | 1ml | Out of stock | 8-10 business days | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20251116 | 100mg | In stock | Shanghai, Shenzhen | Inquiry | |
| Batchno.20260310 | 10g | In stock | Shanghai, Shenzhen, Chengdu | Inquiry | |
| Batchno.20250424 | 10mg | In stock | Shanghai, Tianjin, Wuhan | Inquiry | |
| Batchno.20250627 | 1g | In stock | Shanghai, Tianjin, Chengdu | Inquiry | |
| Batchno.20250710 | 1mg | In stock | Shanghai, Tianjin | Inquiry | |
| Batchno.20250831 | 250mg | In stock | Shanghai, Shenzhen, Wuhan | Inquiry | |
| Batchno.20260107 | 25g | In stock | Shanghai | Inquiry | |
| Batchno.20250313 | 5g | In stock | Shanghai, Tianjin | Inquiry |
- Product code: SSC-019958
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 1g
- Available purity: ≥98%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 1g | ≥98% | 0 Out of Stock | Shanghai | Inquiry |
119413-54-6 / (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
TOPOTECAN HYDROCHLORIDE | Topotecan Hcl | Nogitecan hydrochloride
Basic Information
CAS
119413-54-6
Multi CAS
Yes
Molecular Formula
C23H24ClN3O5
Molecular Weight
457.900000
Exact Mass
457.140449
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
InChI
InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChIKey
DGHHQBMTXTWTJV-BQAIUKQQSA-N
Synonyms
TOPOTECAN HYDROCHLORIDE
Topotecan Hcl
Nogitecan hydrochloride
Evotopin
Topotecan teva
Computed Properties
Structural Parameters
Heavy atom count
32
Aromatic heavy atom count
16
Fraction Csp3
0.35
Rotatable bonds
3
H-bond acceptors
8
H-bond donors
2
Molar refractivity
120.83
TPSA
104.89
LogP / Solubility
WLOGP
2.27
MLOGP
2.03
XLogP3
2.27
Consensus LogP
2.19
Log S (ESOL)
-4.28
Class (ESOL)
Slightly soluble
Log S (Ali)
-4.95
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.88
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.9
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
PAINS alerts
1
Leadlikeness
No
Synthetic Accessibility
4
Safety & Transport
Pictogram(s)
Acute Toxic
Irritant
Health Hazard
Signal
Danger
GHS Hazard Statements
H300 (37.5%): Fatal if swallowed [Danger Acute toxicity, oral]
H301 (12.5%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (12.5%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (12.5%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (12.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Precautionary Statement Codes
P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
