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CAS 118362-03-1 5′-O-(4,4-Dimethoxytrityl)-2′-O-[(tert-butyl)dimethylsilyl]uridine-3′-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite molecular structure lightbox
CAS RN: 118362-03-1

5′-O-(4,4-Dimethoxytrityl)-2′-O-[(tert-butyl)dimethylsilyl]uridine-3′-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Product Availability

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1 package records1 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250105 1g / 5g / 10g / 25g Confirm by inquiry Shanghai Inquiry
  • Product code: SSC-018134
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g, 1g, 5g, 25g
  • Available purity: ≥98%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 118362-03-1
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥98% 0 Out of Stock Hong Kong Inquiry
1g ≥98% 0 Out of Stock Shenzhen Inquiry
5g ≥98% 0 Out of Stock Hong Kong Inquiry
25g ≥98% 0 Out of Stock Hong Kong Inquiry

118362-03-1 / 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

rU Phosphoramidite | R6TND9K9NF | DTXSID50447507

Standard CAS: 118362-03-1 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
118362-03-1
Multi CAS
Yes
Molecular Formula
C45H61N4O9PSi
Molecular Weight
861.000000
Exact Mass
860.394543
SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
InChI
InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1
InChIKey
SKNLXHRBXYGJOC-ZMHKPELYSA-N
Synonyms
rU Phosphoramidite R6TND9K9NF DTXSID50447507 RefChem:1098167 DTXCID50398328

Computed Properties

Structural Parameters

Heavy atom count
60
Aromatic heavy atom count
24
Fraction Csp3
0.49
Rotatable bonds
19
H-bond acceptors
12
H-bond donors
1
Molar refractivity
235.65
TPSA
146.5

LogP / Solubility

WLOGP
8.51
MLOGP
7.57
XLogP3
8.51
Consensus LogP
8.2
Log S (ESOL)
-9.58
Class (ESOL)
Insoluble
Log S (Ali)
-12.77
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-14.6
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.93

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
7.5

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