![CAS 1144035-53-9 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1144035-53-9.gif)
CAS RN: 1144035-53-9
4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
Product Availability
Choose a grade to view its available package options.
9 package records3 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250413 | 5mg / 25mg / 100mg | Out of stock | 8-10 business days | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250818 | 100mg | Out of stock | Inquiry | ||
| Batchno.20260402 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20250621 | 1g | Out of stock | Inquiry | ||
| Batchno.20250201 | 1mg | In stock | Shanghai | Inquiry | |
| Batchno.20260420 | 250mg | Out of stock | Inquiry | ||
| Batchno.20250114 | 25mg | Out of stock | Inquiry | ||
| Batchno.20260608 | 50mg | Out of stock | Inquiry | ||
| Batchno.20250628 | 5mg | In stock | Shanghai | Inquiry |
- Product code: starshine_CAS1144035-53-9
- Purity/Analytical Methods: >99.0%
1144035-53-9 / (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate
PF-8380 | PF8380 | PF 8380
Basic Information
CAS
1144035-53-9
Multi CAS
Yes
Molecular Formula
C22H21Cl2N3O5
Molecular Weight
478.300000
Exact Mass
477.085826
SMILES
C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl
InChI
InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29)
InChIKey
JMSUDQYHPSNBSN-UHFFFAOYSA-N
Synonyms
PF-8380
PF8380
PF 8380
T582DIM5A4
2(3H)-Benzoxazolone, 6-(1-oxo-3-(1-piperazinyl)propyl)-
Computed Properties
Structural Parameters
Heavy atom count
32
Aromatic heavy atom count
15
Fraction Csp3
0.32
Rotatable bonds
6
H-bond acceptors
6
H-bond donors
1
Molar refractivity
120.44
TPSA
95.85
LogP / Solubility
WLOGP
3.96
MLOGP
3.51
XLogP3
3.2
Consensus LogP
3.56
Log S (ESOL)
-5.25
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.34
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.77
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.83
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
Customers Also Viewed
-
2-(4-chlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride
- CAS RN: 1144037-44-4
- Product Code: starshine_CAS1144037-44-4
- Purity/Analytical method: >99.0%
-
CWP232228
- CAS RN: 1144044-02-9
- Product Code: starshine_CAS1144044-02-9
- Purity/Analytical method: >99.0%
-
N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N’-methylurea
- CAS RN: 1144068-46-1
- Product Code: starshine_CAS1144068-46-1
- Purity/Analytical method: >99.0%
-
-
Cyanine7 carboxylic acid
- CAS RN: 1144107-78-7
- Product Code: starshine_CAS1144107-78-7
- Purity/Analytical method: >99.0%
-
2-bromo-5-propoxypyridine
- CAS RN: 1144110-15-5
- Product Code: starshine_CAS1144110-15-5
- Purity/Analytical method: >99.0%
![CAS 1144068-46-1 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N’-methylurea molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1144068-46-1.gif)
