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CAS 1086062-66-9 GSK-2126458 molecular structure lightbox
CAS RN: 1086062-66-9

GSK-2126458

Product Availability

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13 package records11 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260512 100mg In stock Shanghai Inquiry
Batchno.20250204 10mg In stock Shanghai Inquiry
Batchno.20260402 1mg In stock Shanghai Inquiry
Batchno.20260328 250mg Out of stock Inquiry
Batchno.20250816 2mg In stock Shanghai Inquiry
Batchno.20250102 50mg In stock Shanghai Inquiry
Batchno.20260623 5mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250627 100mg Out of stock Inquiry
Batchno.20250414 10mg In stock Inquiry
Batchno.20250723 25mg In stock Inquiry
Batchno.20250623 2mg In stock Inquiry
Batchno.20251102 50mg In stock Inquiry
Batchno.20250226 5mg In stock Inquiry
  • Product code: SSC-009849
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1086062-66-9
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

1086062-66-9 / 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)-3-pyridinyl]benzenesulfonamide

Omipalisib | GSK2126458 | GSK-2126458

Standard CAS: 1086062-66-9 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1086062-66-9
Multi CAS
Yes
Molecular Formula
C25H17F2N5O3S
Molecular Weight
505.500000
Exact Mass
505.102017
SMILES
COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
InChI
InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
InChIKey
CGBJSGAELGCMKE-UHFFFAOYSA-N
Synonyms
Omipalisib GSK2126458 GSK-2126458 GSK 2126458 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Computed Properties

Structural Parameters

Heavy atom count
36
Aromatic heavy atom count
28
Fraction Csp3
0.04
Rotatable bonds
6
H-bond acceptors
7
H-bond donors
1
Molar refractivity
129.72
TPSA
106.96

LogP / Solubility

WLOGP
4.84
MLOGP
4.3
XLogP3
3.3
Consensus LogP
4.15
Log S (ESOL)
-6.2
Class (ESOL)
Insoluble
Log S (Ali)
-7.2
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.68
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.37

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
5

Safety & Transport

Pictogram(s)
Acute Toxic Irritant Health Hazard
Signal
Danger
GHS Hazard Statements
H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral] H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral] H341 (50%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] H361 (50%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H361fd (50%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]
Precautionary Statement Codes
P203, P260, P264, P270, P280, P301+P316, P301+P317, P318, P319, P321, P330, P405, and P501

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