502 °F at 760 mmHg (NTP, 1992)
261 °C at 760 mm Hg
261 °C
Density
1.234 at 68 °F (NTP, 1992) - Denser than water; will sink
1.503 (also given as 1.104 and 1.234)
Bulk density: 47.2 lb/cu ft
Relative density (water = 1): 1.503
Physical Description
Succinic anhydride appears as colorless needles or white crystalline solid. Melting point 237 °F. Sublimes at 239 °F at 5 mmHg pressure; and at 198 °F and 1 mmHg pressure. Moderately toxic and an irritant.
Dry Powder; Liquid; Pellets or Large Crystals
Colorless or light-colored solid; [Hawley] Odorless; [HSDB] White crystalline solid;
Solid
COLOURLESS CRYSTALS OR FLAKES.
Appearance
NEEDLES FROM ALC; RHOMBIC PYRAMIDS FROM CHLOROFORM OR CARBON TETRACHLORIDE
COLORLESS OR LIGHT-COLORED NEEDLES OR FLAKES
Orthorhombic prisms from abs alc.
Succinic anhydride forms rhombic pyramidal or bipyramidal crystals.
State
Solid
Storage Conditions
STORAGE PRECAUTIONS: You should store this material at ambient temperatures, and protect it from moisture. (NTP, 1992)
Computed Properties
Structural Parameters
Heavy atom count
7
Fraction Csp3
0.5
H-bond acceptors
3
Molar refractivity
20.33
TPSA
43.37
LogP / Solubility
WLOGP
-0.15
MLOGP
-0.14
XLogP3
-0.5
Consensus LogP
-0.26
Log S (ESOL)
-0.37
Class (ESOL)
Very soluble
Log S (Ali)
-0.27
Class (Ali)
Very soluble
Log S (SILICOS-IT)
-0.19
Class (SILICOS-IT)
Very soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.44
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
1.5
Safety & Transport
Pictogram(s)
Corrosive
Irritant
Health Hazard
Signal
Danger
Warning
GHS Hazard Statements
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]