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CAS 1051375-10-0 Cabotegravir (GSK744, GSK1265744) molecular structure lightbox
CAS RN: 1051375-10-0

Cabotegravir (GSK744, GSK1265744)

Product Availability

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11 package records9 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260118 100mg In stock Shanghai, Wuhan, Chengdu Inquiry
Batchno.20250401 10g In stock Shanghai Inquiry
Batchno.20260619 1g In stock Shanghai, Wuhan, Chengdu Inquiry
Batchno.20260630 250mg In stock Shanghai, Shenzhen Inquiry
Batchno.20260405 50mg In stock Shanghai Inquiry
Batchno.20260516 5g In stock Shanghai, Tianjin Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251016 100mg / 250mg / 1g Out of stock 5-7 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260605 10mg In stock Inquiry
Batchno.20250406 1g Out of stock Inquiry
Batchno.20251017 250mg In stock Inquiry
Batchno.20251125 50mg In stock Inquiry
  • Product code: SSC-006875
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1051375-10-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g ≥95% 0 Out of Stock Shenzhen Inquiry

1051375-10-0 / (3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide

Cabotegravir | GSK744 | GSK1265744A

Standard CAS: 1051375-10-0 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1051375-10-0
Multi CAS
Yes
Molecular Formula
C19H17F2N3O5
Molecular Weight
405.400000
Exact Mass
405.113627
SMILES
C[C@H]1CO[C@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
InChI
InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1
InChIKey
WCWSTNLSLKSJPK-LKFCYVNXSA-N
Synonyms
Cabotegravir GSK744 GSK1265744A Apretude GSK744 LAP

Computed Properties

Structural Parameters

Heavy atom count
29
Aromatic heavy atom count
12
Fraction Csp3
0.32
Rotatable bonds
3
H-bond acceptors
6
H-bond donors
2
Molar refractivity
95.27
TPSA
100.87

LogP / Solubility

WLOGP
0.96
MLOGP
0.87
XLogP3
2.1
Consensus LogP
1.31
Log S (ESOL)
-3.07
Class (ESOL)
Poorly soluble
Log S (Ali)
-3.58
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.45
Class (SILICOS-IT)
Poorly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-4.51

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4

Safety & Transport

Pictogram(s)
Environmental Hazard
Signal
Warning
GHS Hazard Statements
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes
P273, P391, and P501

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