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CAS 1047634-65-0 GSK2141795 molecular structure lightbox
CAS RN: 1047634-65-0

GSK2141795

Product Availability

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14 package records13 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260410 100mg In stock Shanghai Inquiry
Batchno.20251102 10mg In stock Shanghai Inquiry
Batchno.20260308 1g Out of stock Inquiry
Batchno.20250315 1mg In stock Shanghai Inquiry
Batchno.20250504 250mg In stock Shanghai Inquiry
Batchno.20260422 25mg In stock Shanghai Inquiry
Batchno.20260701 50mg In stock Shanghai Inquiry
Batchno.20250303 5mg In stock Shanghai Inquiry
Batchno.20250216 5mg / 25mg / 100mg Confirm by inquiry Shanghai 5-7 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250225 100mg In stock Inquiry
Batchno.20251201 10mg In stock Inquiry
Batchno.20250815 1mg In stock Inquiry
Batchno.20251205 25mg In stock Inquiry
Batchno.20260623 5mg In stock Inquiry
  • Product code: SSC-006489
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1047634-65-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

1047634-65-0 / N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-1-methylpyrazol-5-yl)furan-2-carboxamide

Uprosertib | GSK2141795 | GSK-2141795

Standard CAS: 1047634-65-0 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1047634-65-0
Multi CAS
Yes
Molecular Formula
C18H16Cl2F2N4O2
Molecular Weight
429.200000
Exact Mass
428.061838
SMILES
CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)N[C@@H](CC3=CC(=C(C=C3)F)F)CN)Cl
InChI
InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChIKey
AXTAPYRUEKNRBA-JTQLQIEISA-N
Synonyms
Uprosertib GSK2141795 GSK-2141795 GSK2141795C Uprosertib [USAN:INN]

Computed Properties

Structural Parameters

Heavy atom count
28
Aromatic heavy atom count
16
Fraction Csp3
0.22
Rotatable bonds
6
H-bond acceptors
5
H-bond donors
2
Molar refractivity
101.3
TPSA
86.08

LogP / Solubility

WLOGP
3.56
MLOGP
3.16
XLogP3
3.4
Consensus LogP
3.37
Log S (ESOL)
-4.77
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.65
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-6.13
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.81

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

Safety & Transport

Pictogram(s)
Health Hazard
Signal
Danger
GHS Hazard Statements
H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
Precautionary Statement Codes
P260, P264, P270, P319, and P501

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