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CAS 103878-83-7 N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid molecular structure lightbox
CAS RN: 103878-83-7

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

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1 package records0 with current stock1 grade group
Batch No.PackageAvailabilityLead TimeInquiry
Batchno.20260327 10mg / 25mg Out of stock 15 business days Inquiry
  • Product code: starshine_CAS103878-83-7
  • Purity/Analytical Methods: >99.0%
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103878-83-7 / N-(2-aminoethyl)-5-chloropyridine-2-carboxamide;hydrochloride

Lazabemide hydrochloride | Tempium | Lazabemide HCl

Standard CAS: 103878-83-7 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
103878-83-7
Multi CAS
Yes
Molecular Formula
C8H11Cl2N3O
Molecular Weight
236.100000
Exact Mass
235.027917
SMILES
C1=CC(=NC=C1Cl)C(=O)NCCN.Cl
InChI
InChI=1S/C8H10ClN3O.ClH/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H
InChIKey
JMFKTFLARGGXCC-UHFFFAOYSA-N
Synonyms
Lazabemide hydrochloride Tempium Lazabemide HCl Lazabemide monohydrochloride Ro 19-6327/001

Computed Properties

Structural Parameters

Heavy atom count
14
Aromatic heavy atom count
6
Fraction Csp3
0.25
Rotatable bonds
3
H-bond acceptors
3
H-bond donors
2
Molar refractivity
57.88
TPSA
68.01

LogP / Solubility

WLOGP
0.85
MLOGP
0.75
XLogP3
0.85
Consensus LogP
0.82
Log S (ESOL)
-1.96
Class (ESOL)
Soluble
Log S (Ali)
-2.11
Class (Ali)
Moderately soluble
Log S (SILICOS-IT)
-2.26
Class (SILICOS-IT)
Moderately soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.56

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
1.5

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