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CAS 1034148-15-6 AZD2906 molecular structure lightbox
CAS RN: 1034148-15-6

AZD2906

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Batch No.PackageAvailabilityLead TimeInquiry
Batchno.20250726 5mg / 10mg Out of stock 5-7 business days Inquiry
  • Product code: starshine_CAS1034148-15-6
  • Purity/Analytical Methods: >99.0%
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1034148-15-6 / N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxy-3-pyridinyl)propan-2-yl]cyclopropanecarboxamide

AZD2906 | AZD-2906 | SN8JN2RU5L

Standard CAS: 1034148-15-6 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1034148-15-6
Multi CAS
Yes
Molecular Formula
C26H25FN4O3
Molecular Weight
460.500000
Exact Mass
460.191069
SMILES
C[C@@H]([C@@H](C1=CN=C(C=C1)OC)OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(C=C4)F)NC(=O)C5CC5
InChI
InChI=1S/C26H25FN4O3/c1-16(30-26(32)17-3-4-17)25(18-5-12-24(33-2)28-14-18)34-22-10-11-23-19(13-22)15-29-31(23)21-8-6-20(27)7-9-21/h5-17,25H,3-4H2,1-2H3,(H,30,32)/t16-,25-/m0/s1
InChIKey
YDRQCGICZKAGCQ-LMKMVOKYSA-N
Synonyms
AZD2906 AZD-2906 SN8JN2RU5L n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide N-((1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yl)oxy-1-(6-methoxypyridin-3-yl)propan-2-yl)cyclopropanecarboxamide

Computed Properties

Structural Parameters

Heavy atom count
34
Aromatic heavy atom count
21
Fraction Csp3
0.27
Rotatable bonds
8
H-bond acceptors
6
H-bond donors
1
Molar refractivity
125.51
TPSA
78.27

LogP / Solubility

WLOGP
4.6
MLOGP
4.08
XLogP3
4.3
Consensus LogP
4.33
Log S (ESOL)
-5.52
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.66
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.43
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.26

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4.5

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