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CAS 1032900-25-6 Ceritinib (LDK378) molecular structure lightbox
CAS RN: 1032900-25-6

Ceritinib (LDK378)

Product Availability

Choose a grade to view its available package options.

8 package records7 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251019 5mg / 25mg / 100mg / 250mg / 1g Confirm by inquiry Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251226 5mg / 25mg / 100mg / 250mg / 1g / 5g Confirm by inquiry Shanghai, Chongqing, Hebei, Shandong Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250816 100mg In stock Shanghai, Shenzhen Inquiry
Batchno.20260225 1g In stock Shanghai, Shenzhen, Tianjin, Chengdu Inquiry
Batchno.20260128 250mg In stock Shanghai, Shenzhen, Tianjin, Chengdu Inquiry
Batchno.20260330 25g Out of stock Inquiry
Batchno.20250517 5g In stock Shanghai, Shenzhen, Tianjin Inquiry
Batchno.20250629 5mg In stock Shanghai Inquiry
  • Product code: SSC-004740
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1032900-25-6
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g ≥95% 0 Out of Stock Hong Kong Inquiry

1032900-25-6 / 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

ceritinib | LDK378 | ZYKADIA

Standard CAS: 1032900-25-6 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1032900-25-6
Multi CAS
Yes
Molecular Formula
C28H36ClN5O3S
Molecular Weight
558.100000
Exact Mass
557.222739
SMILES
CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
InChI
InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
InChIKey
VERWOWGGCGHDQE-UHFFFAOYSA-N
Synonyms
ceritinib LDK378 ZYKADIA LDK-378 NVP-LDK378-NX

Computed Properties

Structural Parameters

Heavy atom count
38
Aromatic heavy atom count
18
Fraction Csp3
0.43
Rotatable bonds
9
H-bond acceptors
8
H-bond donors
3
Molar refractivity
154.16
TPSA
105.24

LogP / Solubility

WLOGP
6.36
MLOGP
5.64
XLogP3
6.4
Consensus LogP
6.13
Log S (ESOL)
-7.07
Class (ESOL)
Insoluble
Log S (Ali)
-8.73
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-9.65
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.61

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
Yes
Egan
No
Muegge
No
Bioavailability score
0.17
Leadlikeness
No
Synthetic Accessibility
4.5

Safety & Transport

Pictogram(s)
Irritant Health Hazard Environmental Hazard
Signal
Danger
GHS Hazard Statements
H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral] H360 (16.7%): May damage fertility or the unborn child [Danger Reproductive toxicity] H372 (66.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H400 (16.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (66.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes
P203, P260, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501

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