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CAS 1025065-69-3 SGI-1776 molecular structure lightbox
CAS RN: 1025065-69-3

SGI-1776

Product Availability

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10 package records10 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251020 10mg / 50mg / 100mg / 250mg Confirm by inquiry Shanghai 8-10 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251025 100mg In stock Shanghai, Shenzhen, Tianjin, Wuhan, Chengdu Inquiry
Batchno.20250226 10mg In stock Shanghai Inquiry
Batchno.20250620 1g In stock Shenzhen, Tianjin Inquiry
Batchno.20250706 1mg In stock Shanghai Inquiry
Batchno.20250503 250mg In stock Shanghai, Shenzhen, Tianjin Inquiry
Batchno.20250103 25mg In stock Shanghai Inquiry
Batchno.20251228 50mg In stock Shanghai Inquiry
Batchno.20251207 5mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250316 1ml In stock Inquiry
  • Product code: SSC-003758
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1025065-69-3
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g ≥95% 0 Out of Stock Beijing Inquiry

1025065-69-3 / N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

SGI-1776 | SGI-1776 free base | N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine

Standard CAS: 1025065-69-3 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1025065-69-3
Multi CAS
Yes
Molecular Formula
C20H22F3N5O
Molecular Weight
405.400000
Exact Mass
405.177645
SMILES
CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
InChI
InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
InChIKey
MHXGEROHKGDZGO-UHFFFAOYSA-N
Synonyms
SGI-1776 SGI-1776 free base N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine MFCD16659064

Computed Properties

Structural Parameters

Heavy atom count
29
Aromatic heavy atom count
15
Fraction Csp3
0.4
Rotatable bonds
5
H-bond acceptors
6
H-bond donors
1
Molar refractivity
103.82
TPSA
54.69

LogP / Solubility

WLOGP
4.05
MLOGP
3.59
XLogP3
4.3
Consensus LogP
3.98
Log S (ESOL)
-4.96
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.81
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-6.26
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.32

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

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